Singapore was donor to the Global Fund during its establishment and early years with a total contribution of US$ 1 million between 2001 – 2010. This was especially highlighted at the Seventh Board Meeting of the Global Fund in the Executive Director Report, which acknowledged Singapore as a new donor.

Singapore championed a coordinated response to COVID-19 led by global actors – including WHO, GAVI, the Vaccine Alliance and Coalition for Epidemic Preparedness Innovations (CEPI). In addition, Singapore was an early supported of the COVAX Facility, which was established under the vaccines pillar of the ACT Accelerator as the flagship global mechanism to secure fair and equitable access to COVID-19 vaccines for all countries, regardless of income level or development status.

Singapore supports the 2030 Agenda and participated actively in the negotiations on the 2030 Agenda and continue to support efforts to implement and achieve the SDGs globally. 

As a small island state, Singapore is highly economically dependent on global markets and international trade which have been severely disrupted by the COVID-19 pandemic. Singapore, although not a G20 member, has been invited to participate in the G20 Summits and its related processes from 2010 to 2011 and from 2013 to 2021. Singapore has been usually invited as the Convenor of the Global Governance Group (3G), which is an informal grouping of 30 small and medium-sized members of the United Nations established by Singapore in 2009 to, inter alia, promote greater dialogue between the G20 and the broader UN membership. 

On 26 January 2021, the G20 established the High Level Independent Panel (HLIP) on Financing the Global Financing the Global Commons for Pandemic Preparedness and Response. Mr Tharman Shanmugaratnam, Senior Minister and Coordinating Minister for Social Policies, Singapore was one of the co-chairs of the HLIP.